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Rockefeller University Bioinformatics Assistant, Human Genetics of infectious Disease in New York, New York

Job: IRC26068


Job Title Bioinformatics Assistant, Human Genetics of infectious Disease

Laboratory / Department Human Genetics of Infectious Diseases

Department Description

The Laboratory of Human Genetics of Infectious Diseases studies the genetics of human predisposition to pediatric infectious diseases, particularly mycobacterial diseases, invasive pneumococcal diseases and herpes simplex encephalitis. It aims to identify Mendelian 'holes' in the immune defense of otherwise healthy children who are susceptible to specific infectious diseases, work that has profound implications for and has resulted in a paradigm shift in human clinical medicine and fundamental immunology. In the past decade, the laboratory has uncovered that single genetic lesions in children confer severe and selective vulnerability to certain illnesses, whereas corresponding infections in adults result more from polygenetic inheritance. This work not only blurs the distinction between patient-based Mendelian genetics and population-based complex genetics but has also provided experimental support for a unified theory of human infectious diseases.

Detailed Description

The Bioinformatics Assistant will join the growing dry division in the Laboratory of Human Genetics of Infectious Disease and aid in the handling of an expanding dataset of whole exome/whole genome sequences from 15,000 individuals with a wide range of infectious diseases, including COVID-19. Will be involved in the evaluation, development, validation, and implementation of new tools for the genetic data analysis; including generating bioinformatic pipelines, testing/validation of scripts, and running web servers. Responsibilities include assisting in data acquisition, analysis, and annotation for depositing to federal databases. Will also aid in providing bioinformatics support to laboratory members and external collaborators. Additional responsibilities include maintenance of in-house servers and communication with IT for university-managed servers. The laboratory offers an excellent multidisciplinary environment comprising computational scientists and experimentalists.

Job Requirements

Bachelor's degree in science required; educational emphasis in bioinformatics, computer science, or related fields preferred. Must have familiarity with Linux environment and shell script writing/running. Must have programming experience in Python or equivalent. Knowledge of SQL database development and prior experience in next-generation sequencing data analyses is a plus. Excellent verbal and written communication skills are required. Motivation is a must.

Additional Details

The Rockefeller University is an Equal Opportunity Employer - Minorities/Women/Disabled/Veterans