Rockefeller University Bioinformatics Specialist, Chemical Immunology and Proteomics in New York, New York
Job Title Bioinformatics Specialist, Chemical Immunology and Proteomics
Laboratory / Department Chemical Immunology and Proteomics
The Laboratory of Chemical Immunology and Proteomics applies synthetic chemistry, chemical biology, and proteomics methods toward the goals of discovering and characterizing (a) novel selective chemical probes that perturb the functions of key proteins regulating immunological and neuroimmunological processes; (b) new mechanisms for small molecule-induced protein degradation; and, more broadly, (c) the pharmacological landscape and signal transduction pathways in immune and neuroimmunological disorders. Achieving these objectives is enhanced through the development of new chemical scaffolds targeting cysteine and other nucleophilic residues. By developing and applying innovative chemical proteomic profiling technologies, we aim to enrich our understanding of the molecular differences between pathologic and physiologic states in immune cells and cells of the nervous system (including microglia and oligodendrocytes, which are implicated in the autoimmune disorder multiple sclerosis). The lab also plans to explore how those differences can be further leveraged from a pharmacological perspective for the development of new therapies that not only target specific immune cell subtypes, but also the defined activation states of these cells. Please see www.vinogradovalab.com for more information.
The Bioinformatics Assistant will join the newly established Laboratory of Chemical Immunology and Proteomics and will have evolving responsibilities with an overall objective of facilitating proteomics workflows for data processing and production of high-quality data. As a founding member of the laboratory, the Bioinformatics Assistant will have a significant impact on the long-term design and culture of the Laboratory, the opportunity to work directly with the Head of the Laboratory establishing both the organization and culture of the Laboratory, and extensive opportunities to gain new skills through interactions with colleagues and collaborators in other labs. In particular, the Bioinformatics Assistant will support general laboratory operations through the augmentation and development of data processing workflows for large proteomics datasets; development and application of data analysis and visualization tools, including integrative analyses of omics data; and generation of a web-based data portal for large proteomics dataset storage, searching, and visualization. If inclined, the Bioinformatics Assistant will have an opportunity to work with the Head of Laboratory, graduate students, and postdocs on wet lab work, including tissue culture, flow cytometry, mass-spectrometry, and standard molecular biology to support ongoing projects. Will have the opportunity to develop an independent research project within the scope of the Laboratory's interests, under the mentorship of the Head of Laboratory.
Bachelor's degree in science required; Master's degree preferred. Educational emphasis in computational biology, computer science, bioinformatics, biostatistics, mathematics, or a related field preferred. Must have at least one year of work experience in large scale data analysis, preferably in proteomics or NGS. Must be proficient in R, Python, and other relevant computer languages, with working knowledge of statistical methods and data analysis methods. Experience creating and working with Web-based databases is preferred. Experience in large scale data analysis required. Must have excellent critical thinking, research, and analytical skills, as well as the ability to work independently as well as part of a team in a fast-paced, highly collaborative environment. Strong organizational, record-keeping, and interpersonal skills required.
The Rockefeller University is an Equal Opportunity Employer - Minorities/Women/Disabled/Veterans