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Rockefeller University Bioinformatics Specialist I (Salary Range: $75K-$95K) in New York, New York

Job: IRC28590


Job Title Bioinformatics Specialist I (Salary Range: $75K-$95K)

Laboratory / Department Systems Cancer Biology

Department Description

Cancer remains a daunting problem despite decades of active research into its molecular causes. Such studies have predominantly focused on the earliest stages of cancer progression such as the formation of a cancer or genes involved in the growth of the primary tumor. In humans afflicted by cancer, the primary tumor is typically surgically resected or eliminated by radiation. Vast numbers of patients, nonetheless die of cancer as a result of metastasis, or the spread of cancer cells from the primary tumor site to distal organs. This process is in fact the overwhelming cause of death from cancer and its occurrence changes a patient's prognosis to incurable. Despite its vast clinical significance and inherently fascinating underlying biology, the metastatic program is poorly understood both at the molecular level and at the cellular/tissue micro-environment levels. Our laboratory employs a multi-disciplinary approach involving molecular, biochemical, computational, imaging, and clinical association methods to characterize the critical regulatory pathways that mediate the steps of this process. By implanting human cancer cells obtained from patients with breast or colon cancer into recipient mice, we study and interfere with the various stages of metastasis. By comparing human cancer cells that are highly metastatic to those that fail to metastasize, we have uncovered a set of small RNA molecules (microRNAs) that suppress metastasis. Our future work is aimed at gaining a better understanding of the mechanisms by which these microRNAs block metastasis. Our hope is that a better understanding of this process will enhance our therapeutic arsenal against it.

Detailed Description

The Bioinformatic Specialist will assist laboratory researchers within the Laboratory of Systems Cancer Biology and two associated laboratories funded by a prestigious National Cancer Institute Metastasis Network Award. The Bioinformatic Specialist will provide effective data analysis, organizing of genome-wide transcriptomics and genomic DNA information, create new pipelines for genomic data, maintain existing pipelines, and helping to interpret results. Expert Computational biology supervision will also be provided by the Biological Sciences and Systems Biology professor at Columbia University, another member of the MetNet Center. The Bioinformatics Specialist will also serve as the MetNet Center Data Manager and will oversee the organization, storage, inter-project transmission, and external transmission of data generated by the Center. The Bioinformatics Specialist will participate in the organization of data and generation of reports for the External Advisory Committee, Executive Board, and the MetNet consortium and will also sit on the Resource and Data Sharing Working Group of the MetNet. Targeted salary is $75,000 to $95,000.

Job Requirements

Master's degree required; educational emphasis in computational biology, computer science, biological sciences, or other related analytical disciplines, preferred. Excellent programming skills in at least one scripting language such as Perl, Python, or R. Must be comfortable working in Unix/Linux environments and using the command line. Ability to multitask while working independently and exercising good judgment in terms of meeting deadlines. Ability to maintain well-documented, tested codes and analysis results. Must be motivated and willing to learn new technologies, contribute to publications in peer-reviewed journals, and have strong communication skills with the ability to interact with other researchers from diverse scientific backgrounds. Prior experience in scientific programming with applications to biomedical research, preferably in genomics and next-generation sequencing analysis.

Additional Details

This job requires that employees be fully vaccinated against COVID-19 as a condition of employment. Rockefeller University provides reasonable accommodations where legally required including accommodations for medical conditions and sincerely held religious beliefs.

The Rockefeller University is an Equal Opportunity Employer - Minorities/Women/Disabled/Veterans