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Rockefeller University Postdoctoral Associate, Human Genetics of Infectious Diseases in New York, New York

Job: IRC26129


Job Title Postdoctoral Associate, Human Genetics of Infectious Diseases

Laboratory / Department Human Genetics of Infectious Diseases

Department Description

The Laboratory of Human Genetics of Infectious Diseases studies the genetics of human predisposition to pediatric infectious diseases, particularly mycobacterial diseases, invasive pneumococcal diseases and herpes simplex encephalitis. It aims to identify Mendelian 'holes' in the immune defense of otherwise healthy children who are susceptible to specific infectious diseases, work that has profound implications for and has resulted in a paradigm shift in human clinical medicine and fundamental immunology. In the past decade, the laboratory has uncovered that single genetic lesions in children confer severe and selective vulnerability to certain illnesses, whereas corresponding infections in adults result more from polygenetic inheritance. This work not only blurs the distinction between patient-based Mendelian genetics and population-based complex genetics but has also provided experimental support for a unified theory of human infectious diseases.

Detailed Description

The Postdoctoral Associate will join the dry lab division of the Laboratory of Human Genetics of Infectious Diseases and participate in the development of novel computational approaches to detect, predict and prioritize genetic variants that could be deleterious and disease-causing. Responsibilities include utilizing existing bioinformatics tools, integrating various biological data, and encoding important biological events for the development of advanced new approaches to decipher the unrevealed role of novel genetic variants in human diseases. Currently, the lab has over 10,000 exome/genome sequenced individuals from a wide range of infectious disease projects. The Postdoctoral Associate will have opportunities to work with the wet-bench investigators across different disease groups to support with functional predictions of the genetic variants and high-throughput genomics/transcriptomics data analyses. Additional responsibilities may include various bioinformatics-related work, including maintaining and updating the in-house exome/genome variant database and the lab-developed webservers.

Job Requirements

Ph.D. in bioinformatics, computational biology, or computer science and previous genomics experience required. Must be familiar with Linux environment and shell script writing/running and have programming experience in Python or equivalent. Must have database/website experience in MySQL and PHP. Prior experience in next-generation sequencing data analyses and/or machine-learning studies is preferred.

Additional Details

Please email your CV and statement of interest to Dr. Jean-Laurent Casanova ( and Dr. Peng Zhang (

The Rockefeller University is an Equal Opportunity Employer - Minorities/Women/Disabled/Veterans