Rockefeller University Research Assistant in New York, New York
Job Title Research Assistant
Laboratory / Department Molecular and Cellular Neuroscience
The Laboratory of Molecular and Cellular Neuroscience studies the molecular defects responsible for neurological and psychiatric disorders including Alzheimer's disease, major depressive disorder, Parkinson's disease, and obsessive compulsive disorder, as well as the molecular mechanisms by which neuro- and psychoactive drugs produce their pharmacological actions in these disorders. Research from the laboratory has demonstrated that most neurotransmitters and neuromodulators achieve their actions and interactions on post-synaptic neurons through a process called "slow synaptic transmission." This process involves activation of highly complex signal transduction cascades. For the last 10 years, the group has applied this knowledge and developed a state-of-the-art methodologies (eg. BacTRAP), to the study of the molecular pathways behind various neurological and psychiatric disorders.
The Research Assistant will contribute to a project aiming to understand the cellular and molecular basis of Major Depressive Disorder using cell culture systems and transgenic mouse models. Experiments include cloning, viral packaging and testing, generation and maintenance of several transgenic mouse lines, and gene and protein analysis including Western blot, qPCR, RNAseq, and immunohistochemistry.
Bachelor's degree in science required; educational emphasis in neuroscience preferred. Strong background in molecular biology (including cloning) and biochemistry (including Western blot analysis) required. Previous work with rodents is a plus.